Is it true that 'obese large-cell type b-cell lymphoma' causes headaches and nausea?

 

Obese large-cell type b-cell lymphoma is a disease that is revealed when you notice swelling of lymph nodes in your neck or legs, or when you feel bad or stuffy. Self-conscious symptoms are often not recognized because there are many symptoms that are easy to occur in other diseases. However, as it is a type of blood cancer, if you feel even the slightest discomfort, consult a medical institution. This time, we will look at the symptoms, tests, and treatment of obese large-cell type b-cell lymphoma.

What is obese large-cell type b-cell lymphoma?

What kind of disease is it?

Obese large-cell type b-cell lymphoma is a type of cancer of the blood (hematopoietic tumor). Representative blood cancers include leukemia, myelodysplastic syndrome, multiple myeloma, and malignant lymphoma. Obese large-cell type b-cell lymphoma is classified as a malignant lymphoma and is known as the most frequent disease among blood cancers.

Malignant lymphoma is largely classified into two types: Hodgkin's lymphoma and non-Hodgkin's lymphoma. Most of them are non-Hodgkin's lymphoma, and obese large-cell type b-cell lymphoma is also one of the non-Hodgkin's lymphomas.

Malignant lymphoma is a disease in which lymphocytes contained within white blood cells become cancerous. Lymphocytes normally flow in a tube called lymphatic vessels, so they are prepared to fight foreign substances such as bacteria that have invaded the body. Lymphatic vessels are next to the large blood vessels in the body and are found in the neck and armpits, chest and abdomen, and in the legs. Therefore, when it becomes obese large-cell type b-cell lymphoma and lymphocytes become cancerous, it is characterized by various symptoms throughout the body.

What are the symptoms of obese large-cell type b-cell lymphoma?

Because obese large-cell type b-cell lymphoma develops in lymph nodes throughout the body, its symptoms vary. Its various symptoms can be broadly divided into local symptoms and systemic symptoms.

What are the local symptoms of obese large-cell type b-cell lymphoma?

Lymph nodes are located close to the outside of the body, so if a disease occurs in the neck, armpit, or leg joints, a hard thing will come into contact with it. Also, if a disease occurs in the lymph node in a place called the mediastinum, which is like dividing both lungs, it may become difficult to breathe or swallow food as the disease grows.

There are also lymph nodes around the intestine, where disease and enlargement put pressure on the intestine itself, which can cause stomach pain. In some cases, a disease in the body presses on nerves, causing paralysis in the arms and legs.

What are the systemic symptoms of obese large-cell type b-cell lymphoma?

Because the lymphocytes inside the lymphatic vessels become cancerous, they cause symptoms in many places where the lymphatic vessels are, but can also cause symptoms elsewhere than the lymphatic vessels. Obese large-cell type b-cell lymphoma can cause abnormalities in liver or kidney function by proliferating in organs such as the liver and kidneys. In addition, if the bone marrow invades the blood-producing area, the ability to produce blood is reduced and the immune function is lowered, so it is easy to get an infectious disease.

Also, there are cases where symptoms such as headache or nausea may appear by penetrating into the brain. In addition, according to the signals emitted by obese large-cell type b-cell lymphoma carried throughout the body through lymphatic vessels, symptoms appear throughout the body, such as excessive night sweats, weight loss, or fever.

Discipline of obese large-cell type b-cell lymphoma

If obese large-cell type b-cell lymphoma is suspected, which department should I see?

Hematology specialists, including obese large-cell type b-cell lymphoma, are hematologists, so it is recommended to see a hematologist. However, if you do not go to a large hospital, there are many cases where there is no hematology department, and it is difficult to get a medical examination suddenly without a letter of referral (medical information provision). Therefore, first consult your local internal medicine clinic, and consult your doctor about the symptoms suspected of obese large-cell type b-cell lymphoma.

What is the screening for obese large-cell type b-cell lymphoma?

What tests are done if obese large-cell type b-cell lymphoma is suspected?

First, blood is drawn to ensure that liver or kidney function has not been compromised by the expression or progression of obese large-cell type b-cell lymphoma. LDH (lactate dehydrogenase) and β2 microglobulin, which are elevated as the disease progresses, are also tested.

In addition to blood collection, CT scans and MRI scans, which are imaging tests, are also performed to specifically investigate where the disease is occurring and to what extent it is progressing. Finally, a needle is inserted directly into the diseased lymph node to examine the tissue to determine whether or not it is obese large-cell type b-cell lymphoma.

What is the treatment for obese large-cell type b-cell lymphoma?

How is obese large-cell type b-cell lymphoma treated?

Because obese large-cell b-cell lymphoma is a type of blood cancer, it is treated with anticancer drugs (chemotherapy). Specifically, as standard chemotherapy for malignant lymphoma, three anticancer drugs called CHOP therapy (vincristine, indoxic acid, and adriamycin) plus adrenocortical hormones are treated.

The reason for adding corticosteroids as well as anticancer drugs is that the action of corticosteroids injures lymphocytes, so it is administered for the purpose of treating cancerous lymphocytes. In particular, in the case of obese large-cell type b-cell lymphoma, in addition to chemotherapy + corticosteroid-based CHOP therapy, R-CHOP therapy with rituximab, a molecular targeting agent, is generally administered. This rituximab is characterized by attacking a molecule called CD20, which is expressed in most B-cell-derived lymphomas.

In addition to chemotherapy, radiation therapy is sometimes combined. This is because chemotherapy can treat obese large-cell type b-cell lymphoma, but an invisible disease may still remain. Radiation therapy is used to properly treat such microscopic diseases.

What are the side effects of treatment for obese large-cell type b-cell lymphoma?

Side effects of CHOP therapy include digestive symptoms (nausea, vomiting, constipation), drowsiness or tingling, and sometimes fever. In addition, as an invisible side effect, bone marrow suppression may cause a decrease in white blood cells, red blood cells, and platelets, which are blood components, or a decrease in liver function or kidney function.

As a result, you may become more susceptible to infection or develop symptoms of anemia. Since there is a clear explanation from the medical staff when starting treatment, listen carefully to the instructions and follow the precautions, and if you have any symptoms of concern, be sure to consult with the medical staff.

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Obese large-cell type b-cell lymphoma is often difficult to recognize at first because of a disease with a variety of symptoms that can also occur with other diseases. However, being vigilant and overlooking the condition for one of the blood cancers can lead to treatment delays. If you have any symptoms of concern, please consult a medical institution as soon as possible.